Name: GA120015: H-Ser(Neu5Acα(2-6)GalNAc)-OH
Brand: martinafruit.com
SKU: 8986693794
Price: 275.00 USD
Availability: InStock
Rating: 4.4266000000000005 (8 reviews)

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Description

GA120015: H-Ser(Neu5Acα(2-6)GalNAc)-OHC22H37N3O16 599. 5 A fully unprotected (free amine, free acid) L serine glycoamino acid carrying a Neu5Ac2 6GalNAc disaccharide. This deprotected building block is suited to use as a reference standard, an enzymatic substrate acceptor, or for conjugation and analytical work rather than direct Fmoc SPPS. The installed glycan is the sialyl Tn antigen (Neu5Ac2 6GalNAc O Ser Thr), a tumor associated carbohydrate antigen and Siglec ligand, used to build

Fmoc-Asn(Ac3AcNH-β-Glc)-OH

/ β-D-Glc-Propyl-Azide / β-Glc-Pr-N3

Fmoc-Ser(beta-D-Cel)-OH (Peracetate)

/ α-GalNAc-Butyl-Carboxy Methyl Ester / α-GalNAc-C4-COOMe

5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosyl)onicacid]-(2→6)-(β-D-galactopyranosyl)-(1→4)-2-acetamido-2-deoxy-β-D-glucopyranoside

α-D-GalNAc-Ser-NH-Biotin

Fmoc-Ser(Glcβ(1-4)Glc)-OH (Peracetate)

Neu5Acα(2-6)Galβ(1-4)GlcNAcβ(1-3)Galβ(1-4)GlcNAcβ(1-3)Galβ(1-4)GlcNAcβ(1-2)Manα(1-3)[Neu5Acα(2-6)Galβ(1-4)GlcNAcβ(1-3)Galβ(1-4)GlcNAcβ(1-3)Galβ(1-4)GlcNAcβ(1-2)Manα(1-6)]Manβ(1-4)GlcNAcβ(1-4)GlcNAcβ-Asn-PEG8-Biotin

enzymatic cleavage of the aglycone-proximal α-glucosidic bond releases 4-nitrophenol

/ Fmoc-Ser(Galβ(1-3)GalNAc)-OH (Peracetate) / TF Epitope (Serine)

enzymatic cleavage releases 4-methylumbelliferone

or enzymatic studies rather than a chain-extendable SPPS building block

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